ANTINEOPLASTIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF

The invention relates to chemical compounds which are obtained by means of in silico molecular modelling and which have a structure that can be used to block phosphorylation by interacting said compounds with the phosphorylation domain or the environment thereof in the substrates of the Casein Kinas...

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Main Authors VERA ALVAREZ, ROBERTO, MAZOLA REYES, YULIET, PEREA RODRIGUEZ, SILVIO ERNESTO, DE LA NUEZ VEULENS, ANIA, MUSACCHIO LASA, ALEXIS, UBIETA GOMEZ, RAIMUNDO, ACEVEDO CASTRO, BORIS ERNESTO, RODRIGUEZ FERNANDEZ, ROLANDO EDUARDO
Format Patent
LanguageEnglish
French
Published 09.12.2014
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to chemical compounds which are obtained by means of in silico molecular modelling and which have a structure that can be used to block phosphorylation by interacting said compounds with the phosphorylation domain or the environment thereof in the substrates of the Casein Kinase II enzyme. The invention also relates to pharmaceutical compositions that contain said compounds and to the use thereof in the preparation of medicaments for the treatment of diseases associated with neoplastic processes.
Bibliography:Application Number: CA20062607298