INHIBITORS OF THE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ENZYME

The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes,...

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Main Authors DINGES, JURGEN, SHUAI, QI, WINN, MARTIN, PATEL, JYOTI R, YONG, HONG, YEH, VINCE S, ROHDE, JEFFREY J, SORENSEN, BRYAN K, LINK, JAMES T
Format Patent
LanguageEnglish
French
Published 01.04.2014
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome and other diseases and conditions that are mediated by excessive glucocorticoid action. La présente invention concerne des composés inhibiteurs de l'enzyme 11-bêta-hydroxystéroïde déshydrogénase de Type 1. La présente invention concerne en outre l'emploi d'inhibiteurs de l'enzyme 11-bêta-hydroxystéroïde déshydrogénase de Type 1 dans le traitement du diabète de type 2 non insulinodépendant, de l'insulinorésistance, de l'obésité, des troubles lipidiques, du syndrome métabolique et d'autres maladies et états pathologiques médiés par une suractivité des glucocorticoïdes.
Bibliography:Application Number: CA20062594098