HETEROCYCLE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS

The present invention relates to compounds of formula I: or pharmaceutically acceptable salts or tautomers thereof, which are inhibitors of histone deacetylase (HDAC). The compounds of the present invention are useful for treating cellular proliferative diseases, including cancer. Further, the compo...

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Main Authors INGENITO, RAFFAELE, SCARPELLI, RITA, ATTENNI, BARBARA, KINZEL, OLAF, SCHULTZ, CARSTEN, FERRIGNO, FEDERICA, JONES, PHILIP, PESCATORE, GIOVANNA, LLAUGER BUFI, LAURA, ROWLEY, MICHAEL, ONTORIA ONTORIA, JESUS MARIA
Format Patent
LanguageEnglish
French
Published 15.06.2006
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to compounds of formula I: or pharmaceutically acceptable salts or tautomers thereof, which are inhibitors of histone deacetylase (HDAC). The compounds of the present invention are useful for treating cellular proliferative diseases, including cancer. Further, the compounds of the present invention are useful for treating neurodegenerative diseases, schizophrenia and stroke among other diseases.
Bibliography:Application Number: CA20052590811