HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION CONTAINING AN AZOLE

• Main Authors: RESNICK, LYNN, BERKOWITZ, JOSHUA D, SABALSKI, JOAN E, HURYN, DONNA M, MORRIS, KOI MICHELE, KREFT, ANTHONY FRANK, KUBRAK, DENNIS MARTIN, CAGGIANO, THOMAS JOSEPH
• Format: Patent
• Language: English; French
• Published: 11.08.2005
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Compounds useful for lowering beta amyloid levels are provided. The compound s have the structure of formula Ia: wherein, RI is lower alkyl, substituted lower alkyl, phenyl, substituted phenyl, benzyl, substituted benzyl, benzyloxy, substituted benzyloxy, or SO2R5; R5 is pheny1, substituted phenyl , heterocycle, substituted heterocycle, alkyl, or substituted alkyl; R2 is low er alkyl, substituted lower alkyl, CF3, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, substituted phenyl, or cycloalkyl; R3 is hydrogen, lower alkyl, or substituted lower alkyl; R4 is phenyl, substituted phenyl, heterocycle, substituted heterocycle, thiophene, or substituted thiophene; R6 is hydrogen, lower alkyl, substituted lower alkyl, CF3, alkeny l, substituted alkenyl, alkynyl, substituted alkyny1, phenyl, substìtuted pheny l, cycloalkyl, or substìtuted cycloalkyl; W, X and Y are independently CR7 or N ; and R7 is hydrogen, halogen, lower alkyl, or substituted lower alkyl.