METHOD FOR THE PRODUCTION OF A CELL AND/OR TISSUE AND/OR DISEASE PHASE SPECIFIC MEDICAMENT

• Main Authors: RENZ, HARALD, SEL, SERDAR
• Format: Patent
• Language: English; French
• Published: 03.06.2014
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The present invention relates to a method for producing of a cell and/or tissue and/or disease phase specific medicament against chronic inflammatory diseases. Disease, cell type, tissue and/or stage specific proteins and nucleic acids are identified with regard to their modified expression pattern and the corresponding nucleic acids are analyzed as possible attack targets for DNAzymes or siRNA. What follows is a design of active specific DNAzymes and siRNA which bind to the target sequence and cleave it such that a medicament against chronic inflammatory diseases and autoimmune diseases is provided. L'invention concerne un procédé servant à produire un médicament spécifique de cellules et/ou de tissus et/ou de phases de maladies et convenant au traitement de maladies inflammatoires chroniques. A cet effet, des protéines et des acides nucléiques spécifiques de la maladie, du type de cellule, du tissu et/ou du stade de la maladie sont identifiés quant à leur profil d'expression modifié et les acides nucléiques correspondants sont analysés en tant que cibles d'attaque possibles pour des ADNzymes ou des ARNsi. On conçoit ensuite des ADNzymes et des ARNsi spécifiques actifs qui se lient à la séquence cible et qui la clivent de sorte qu'on dispose d'un médicament contre des maladies inflammatoires chroniques et contre des maladies auto-immunes.