MACROCYCLIC CARBOXYLIC ACIDS AND ACYLSULFONAMIDES AS INHIBITORS OF HCV REPLICATION

• Main Authors: KENNEDY, APRIL LAYNE, ANDREWS, STEVEN WADE, WENGLOWSKY, STEVEN MARK, WOODARD, BENJAMIN T, JIANG, YUTONG, MADDURU, MACHENDER R, CONDROSKI, KEVIN RONALD, JOSEY, JOHN ANTHONY, DOHERTY, GEORGE ANDREW, BLATT, LAWRENCE M, STENGEL, PETER JOHN
• Format: Patent
• Language: English; French
• Published: 08.12.2009
• Subjects: CHEMISTRY; COMPOSITIONS BASED THEREON; DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; ORGANIC MACROMOLECULAR COMPOUNDS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR CHEMICAL WORKING-UP

The present invention provides compounds of the general formulas I-IX, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The present invention further provides treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition. L'invention concerne des composés représentés par les formules générales I à X, ainsi que des compositions, notamment des compositions pharmaceutiques, contenant un desdits composés. L'invention concerne également des méthodes de traitement, notamment des méthodes de traitement de l'infection par le virus de l'hépatite C et de la fibrose du foie. Ces méthodes consistent en général à administrer à un patient une quantité efficace d'un composé ou d'une composition selon l'invention.