NEW N-HYDROXY-4-(3-PHENYL-5-METHYL-ISOXAZOLE-4-YL)-BENZENESULFONAMIDE SOLVATES

The invention relates to new N-hydroxy-4-(3-phenyl-5-methyl-isoxazole-4-yl)- benzenesulfonamide solvates of formula (I), wherein n represents 0 or 1 mol, [solvate] represents water, C1-C4 alcohol, Cl-C4 alkylester of C1-C3 carboxylic acid or dioxane, and the mixture of solvated (wherein n=1) and sol...

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Main Authors FODOR, TAMAS, KARPATI, EGON, KIS-VARGA, ISTVANNE, ERDELYI, PETER, GERE, ANIKO, FISCHER, JANOS, ZAJERNE BALAZS, MARIA, LEVAI, SANDOR
Format Patent
LanguageEnglish
French
Published 27.01.2005
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The invention relates to new N-hydroxy-4-(3-phenyl-5-methyl-isoxazole-4-yl)- benzenesulfonamide solvates of formula (I), wherein n represents 0 or 1 mol, [solvate] represents water, C1-C4 alcohol, Cl-C4 alkylester of C1-C3 carboxylic acid or dioxane, and the mixture of solvated (wherein n=1) and solvat-free forms (wherein n=0). Furthermore, the invention relates their process for production and use for the treatment of osteoarthritis and rheumatoid arthritis and surgical and primary dysmenorrheal pains, based on anti-inflammatory and analgesic pharmacological model experiments.
Bibliography:Application Number: CA20042530175