RECOMBINANT ANTIBODIES AND FRAGMENTS WHICH RECOGNIZE N GLYCOLIL GM3 GANGLIOSIDE AND ITS USE IN DIAGNOSIS AND TREATMENT OF TUMOURS

The invention essentially relates to the production of less immunogenic immunoglobulins by means of genetic engineering and, more specifically, to a monoclonal antibody recognising antigens which contain ganglioside N-glycolyl-GM3 but not other N-glycolyl- or N-acetyl-type gangliosides nor sulphated...

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Main Authors ROQUE NAVARRO, LOUDES TATIANA, ROJAS DORANTES, GERTRUDIS, TALAVERA PEREZ, ARIEL, MATEO DE ACOSTA DEL RIO, CRISTINA MARIA, RODRIGUEZ GONZALEZ, MABEL, MORENO FRIAS, ERNESTO
Format Patent
LanguageEnglish
French
Published 18.09.2012
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The invention essentially relates to the production of less immunogenic immunoglobulins by means of genetic engineering and, more specifically, to a monoclonal antibody recognising antigens which contain ganglioside N-glycolyl-GM3 but not other N-glycolyl- or N-acetyl-type gangliosides nor sulphated glycolipids. In particular, the invention relates to peptide sequences encoding a recombinant monoclonal antibody against ganglioside N-glycolyl-GM3 or derivative fragments of same. The invention further relates to pharmaceutical compositions containing the aforementioned antibody or fragments thereof and to the diagnostic or therapeutic use of same for breast cancer and melanoma. La présente invention concerne essentiellement la production d'immunoglobulines moins immunogènes par génie génétique, et plus spécifiquement à l'aide d'un anticorps monoclonal reconnaissant les antigènes contenant le ganglioside N-glycolyl GM3 mais pas d'autres gangliosides de type N-glycolyl ou N-acétyl, ni les glycolipides sulfatés. La présente invention concerne plus spécifiquement des séquences peptidiques codant pour un anticorps monoclonal de recombinaison contre le ganglioside n-glycolyl GM3, ou des fragments dérivés de celui-ci, ainsi que des compositions pharmaceutiques contenant ledit anticorps ou ses fragments, et leur utilisation diagnostique ou thérapeutique dans le cancer du sein et les mélanomes.
Bibliography:Application Number: CA20042523449