METHOD FOR TRANSDIFFERENTIATION OF NON-PANCREATIC STEM CELLSTO THE PANCREATIC PATHWAY

The subject invention relates to a method of transdifferentiating mammalian non-pancreatic stem cells, such as mesenchymal stem cells (MSCs), to enter t he pancreatic differentiations pathway. The MSCs are cultured under conditions that permit the expression of pancreatic differentiation markers, an...

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Bibliographic Details
Main Author RAMIYA, VIJAYAKUMAR K
Format Patent
LanguageEnglish
French
Published 14.10.2004
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The subject invention relates to a method of transdifferentiating mammalian non-pancreatic stem cells, such as mesenchymal stem cells (MSCs), to enter t he pancreatic differentiations pathway. The MSCs are cultured under conditions that permit the expression of pancreatic differentiation markers, and these conditions include use of: (a) culture conditions that promote cell clustering; and/or (b) medium comprising glucagon-like peptide-1(GLP-1), hepatocyte growth factor (HGF) and/or nicotinamide.
Bibliography:Application Number: CA20042520861