PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF

• Main Authors: METZ, JAMES G, WEAVER, CRAIG A, FLATT, JAMES H, BARCLAY, WILLIAM R
• Format: Patent
• Language: English; French
• Published: 09.08.2016
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; DAIRY PRODUCTS, e.g. MILK, BUTTER, CHEESE; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; FISHING; FOODS OR FOODSTUFFS; FORESTRY; HUMAN NECESSITIES; HUNTING; MAKING THEREOF; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MILK OR CHEESE SUBSTITUTES; MUTATION OR GENETIC ENGINEERING; NEW PLANTS OR PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES; TRAPPING; VINEGAR; WINE

The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system. D'une manière générale, l'invention concerne des systèmes de polycétides synthase d'acide gras polyinsaturé, des homologues de ceux-ci, des molécules d'acide nucléique isolées et des molécules d'acide nucléique recombinées codant pour des domaines biologiquement actifs de ces systèmes de polycétide synthase d'acide gras polyinsaturé, des organismes génétiquement modifiés comprenant des systèmes de polycétide synthase d'acide gras polyinsaturé, des méthodes de fabrication et d'utilisation de ces systèmes pour la production de molécules bioactives d'intérêt, enfin de nouvelles méthodes d'identification de nouveaux micro-organismes bactériens et non bactériens comprenant ces systèmes de polycétide synthase d'acide gras polyinsaturé.