NON-PEGYLATED LONG-CIRCULATING LIPOSOMES

The present invention provides a long circulating non-pegylated liposomal doxorubicin composition for parenteral administration and a process for its preparation. The circulation time in swiss albino mice is at least 25 times longer than conventional non-liposomal compositions. The non-pegylated lip...

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Bibliographic Details
Main Authors RIVANKAR, SANGEETA HANURMESH, DAFTARY, GAUTAM VINOD, PAI, SRIKANTH ANNAPPA
Format Patent
LanguageEnglish
French
Published 23.08.2011
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention provides a long circulating non-pegylated liposomal doxorubicin composition for parenteral administration and a process for its preparation. The circulation time in swiss albino mice is at least 25 times longer than conventional non-liposomal compositions. The non-pegylated liposomes are stable, exhibit low toxicity and have been found to be efficacious in different tumor models.
Bibliography:Application Number: CA20032511464