HUMAN MONOCLONAL ANTIBODIES AGAINST CD25

• Main Authors: PARREN, PAUL, HAVENITH, CATHARINA EMANUELE GERARDA, WILLIAMS, DENISE LEAH, BAADSGAARD, OLE D. M. SC, SCHUURMAN, JANINE, VAN DE WINKEL, JAN G. J, PETERSEN, JORGEN
• Format: Patent
• Language: English; French
• Published: 27.02.2018
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BEER; BIOCHEMISTRY; CARE OF BIRDS, FISHES, INSECTS; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NEW BREEDS OF ANIMALS; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; SPIRITS; TESTING; TRAPPING; VINEGAR; WINE

Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a hybridoma, a transfectoma or in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals, hybridomas and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies. L'invention concerne des anticorps monoclonaux humains isolés qui se lient à CD25 humain et inhibent ce dernier, ainsi que des compositions et des molécules associées à base d'anticorps. Les anticorps humains peuvent être produits au moyen d'un hybridome, un transfectome ou dans un animal transgénique non humain, par exemple une souris transgénique, capable de produire plusieurs isotypes d'anticorps monoclonaux humains par recombinaison V-D-J et par commutation isotypique. L'invention concerne aussi des compositions pharmaceutiques comprenant les anticorps humains, des animaux transgéniques non humains, des hybridomes et des transfectomes qui produisent les anticorps humains, ainsi que des procédés thérapeutiques et diagnostiques permettant d'utiliser les anticorps humains.