PARENTERAL FORMULATIONS CONTAINING A RAPAMYCIN HYDROXYESTER

This invention provides cosolvent concentrates containing rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid (CCI-779), a parenterally acceptable solvent, and an antioxidant. Also provided are parenteral formulations which contain aforementioned concentrate, diluent solvent,...

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Bibliographic Details
Main Authors HARRISON, MAUREEN M, RUBINO, JOSEPH T, GANDHI, POOJA, SISKAVICH, VICTORIA
Format Patent
LanguageEnglish
French
Published 23.07.2013
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention provides cosolvent concentrates containing rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid (CCI-779), a parenterally acceptable solvent, and an antioxidant. Also provided are parenteral formulations which contain aforementioned concentrate, diluent solvent, and a surfactant and methods for preparing the same. Cette invention se rapporte à des formulations parentérales contenant de l'ester-42 de rapamycine associé à de l'acide 3-hydroxy-2(hydroxyméthyl)-2-méthylpropionique.
Bibliography:Application Number: CA20032493878