PROCESS FOR THE PREPARATION OF 9-BETA-ANOMERIC NUCLEOSIDE ANALOGS

A process for substantially enhancing the regio and stereoselective synthesi s of 9-.beta.-anomeric nucleoside analogs is described. The introduction of th e sugar moiety onto a 6-substituted purine base was preformed so that only the 9- .beta.-D- or L-purine nucleoside analogs were obtained. This r...

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Bibliographic Details
Main Authors MUNK, STEPHEN A, GUPTA, PRANAB K
Format Patent
LanguageEnglish
French
Published 15.01.2008
Subjects
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Summary:A process for substantially enhancing the regio and stereoselective synthesi s of 9-.beta.-anomeric nucleoside analogs is described. The introduction of th e sugar moiety onto a 6-substituted purine base was preformed so that only the 9- .beta.-D- or L-purine nucleoside analogs were obtained. This regio and stereoselective introduction of the sugar moiety allows the synthesis of nucleoside analogs and in particular 2'-deoxy, 3'-deoxy, 2'-deoxy-2'-.beta.- fluoro and 2', 3'-dideoxy-2'-.beta.-fluoro purine nucleoside analogs in high yield without virtually any formation of the 7-positional isomers. The compounds are drugs or intermediates to drugs.
Bibliography:Application Number: CA20032493724