NOVEL HEXAHYDRO-PYRIDAZINE-3-CARBOCYLIC ACID HYDRAZIDE OR HYDRAZONE DERIVATIVES, COMBINATORIAL LIBRARIES CONTAINING SAME, USE THEREOF ASMEDICINES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND METHODS FOR PREPARING SAME

L'invention a pour objet un composé de formule générale (I). L'invention a aussi pour objet les chimiothèques les contenant, leur utilisation comme médicaments, compositions pharmaceutiques et leurs procédés de préparation.< /SDOAB> 2-(N-Substituted aminoalkanoyl or carbamoyl)-hexahy...

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Bibliographic Details
Main Authors GOURVEST, JEAN-FRANCOIS, BROTO, PIERRE, BHATNAGAR, NEERJA, MAUGER, JACQUES
Format Patent
LanguageEnglish
French
Published 24.12.2003
Edition7
Subjects
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Summary:L'invention a pour objet un composé de formule générale (I). L'invention a aussi pour objet les chimiothèques les contenant, leur utilisation comme médicaments, compositions pharmaceutiques et leurs procédés de préparation.< /SDOAB> 2-(N-Substituted aminoalkanoyl or carbamoyl)-hexahydropyridazine-3-carboxylic hydrazide or hydrazone derivatives (I) are new. Hexahydropyridazine derivatives of formula (I), including all possible isomers, racemates, enantiomers and diastereomers, and their mineral or organic acid or base addition salts are new. n = 0-6; R1 = -CO-(CH2)m-R, -CO-NH-(CH2)m-R, -CS-NH-(CH2)m-R or -SO2-(CH2)m-R; m = 0-6, a double bond optionally being present in (CH2)m if m is more than 2; R = H (provided that m is other than 0), OH, SH, CN, OT, aryloxy, aralkoxy or 3-6C cycloalkyl; mono- or bicyclic, saturated or unsaturated heterocyclyl (optionally substituted by 1-3 groups Q); 6-10C aryl or 7-11C aralkyl (both optionally ring-substituted by 1-3 groups Q'); or NR4R5; T = 1-6C alkyl; Q = OH, SH, NH2, NO2, CN, COOH, CONH2, halo, CF3, T, OT, 2-6C acyl, aryl, aralkyl or mono- or bicyclic, saturated or unsaturated heterocyclyl (T, aryl, aralkyl or heterocyclyl being themselves optionally substituted by 1-3 of OH, SH, NH2, NO2, CN, COOH, CONH2, halo or CF3); Q' = as Q but not optionally substituted aryl or aralkyl; R4 = H or T; R5 = H, T or aryl; R2 = H or as for R1; N = R3 = N-R'3 or N=R''3; R'3 = as R1; and R''3 = as R. Independent claims are also included for: (1) Combinatorial libraries of compounds (I), in the form of a row matrix comprising at least two rows each containing at least 2 (preferably at least 5) individual compounds and/or containing at least 4 individual compounds; and (2) The preparation of (I) (optionally in combinatorial library form).
Bibliography:Application Number: CA20032489447