NANOPARTICULATE FIBRATE FORMULATIONS

The present invention is directed to fibrate compositions having improved pharmacokinetic profiles and reduced fed/fasted variability. The fibrate particles of the composition have an effective average particle size of less than about 2000 nm. La présente invention concerne des compositions de fibra...

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Bibliographic Details
Main Authors RYDE, TUULA, GUSTOW, EVAN E, RUDDY, STEPHEN B, PATEL, RAKESH, JAIN, RAJEEV, WILKINS, MICHAEL JOHN
Format Patent
LanguageEnglish
French
Published 18.03.2008
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention is directed to fibrate compositions having improved pharmacokinetic profiles and reduced fed/fasted variability. The fibrate particles of the composition have an effective average particle size of less than about 2000 nm. La présente invention concerne des compositions de fibrate présentant des profils pharmacocinétiques améliorés et une variabilité réduite selon que le patient est à jeun ou non. Les particules de fibrate de la composition ont une taille effective moyenne inférieure à 2000 nm environ.
Bibliography:Application Number: CA20032487054