DNA VACCINES AGAINST HANTAVIRUS INFECTIONS
In this application is described a protective DNA vaccines against infection with HFRS- and HPS-associated hantaviruses. The vaccines were constructed by subcloning cDNA representing the medium (M) (encoding the G1 and G2 glycoproteins) into the DNA expression vector pWRG7077. Animals vaccinated wit...
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Main Authors | , , |
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Format | Patent |
Language | English French |
Published |
15.07.2004
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Edition | 7 |
Subjects | |
Online Access | Get full text |
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Summary: | In this application is described a protective DNA vaccines against infection with HFRS- and HPS-associated hantaviruses. The vaccines were constructed by subcloning cDNA representing the medium (M) (encoding the G1 and G2 glycoproteins) into the DNA expression vector pWRG7077. Animals vaccinated with the M construct developed a neutralizing antibody response. Passive transfer experiments show that serum from vaccinated animals, when injected on days 4 or 5 after challenge, protected animals from lethal disease. |
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Bibliography: | Application Number: CA20032485348 |