PROCESS FOR THE SYNTHESIS OF PEPTIDES

A process is provided for the solid-phase synthesis of a peptide amide which comprises attaching a .alpha.-nitrogen protected C.alpha.-carboxamide amino acid to a solid support by its side chain, removing the .alpha.-nitrogen protecting group, assembling a peptide chain on said .alpha.-nitrogen and...

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Bibliographic Details
Main Authors ATHERTON, ERIC, EVANS, DAVID JOHN, SIMPKIN, DEAN STEVEN ANTHONY, WELLINGS, DONALD ALFRED
Format Patent
LanguageEnglish
French
Published 26.06.2012
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:A process is provided for the solid-phase synthesis of a peptide amide which comprises attaching a .alpha.-nitrogen protected C.alpha.-carboxamide amino acid to a solid support by its side chain, removing the .alpha.-nitrogen protecting group, assembling a peptide chain on said .alpha.-nitrogen and then cleaving the assembled peptide amide from the solid support. Novel amino acid analogues, peptide amides and solid-phase supports are also provided.
Bibliography:Application Number: CA20032484594