DI-ARYL SUBSTITUTED TETRAZOLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5

Tetrazole compounds substituted directly, or by a bridge, with i) a heteroar yl moiety containing N adjacent to the point of connection of the heteroaryl an d ii) another heteroaryl or aryl ring, with at least one of the rings being further substituted with another ring, are mGluR5 modulators useful...

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Main Authors ROPPE, JEFFREY R, SMITH, NICHOLAS D, HUANG, DEHUA, EASTMAN, BRIAN W, POON, STEVEN F, REGER, THOMAS S, COSFORD, NICHOLAS D. P, CHEN, CHIXU
Format Patent
LanguageEnglish
French
Published 25.09.2003
Edition7
Subjects
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Summary:Tetrazole compounds substituted directly, or by a bridge, with i) a heteroar yl moiety containing N adjacent to the point of connection of the heteroaryl an d ii) another heteroaryl or aryl ring, with at least one of the rings being further substituted with another ring, are mGluR5 modulators useful in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, panic, and bipolar disorder, as well as in the treatment of pain, Parkinson s disease, cognitive dysfunction, epilepsy, circadian rhythm disorders, drug addiction, drug abuse, drug withdrawal, obesity and other diseases.
Bibliography:Application Number: CA20032478799