EGF/EGFR COMPLEX

• Main Authors: ISHITANI, RYUICHIRO, SHIROUZU, MIKAKO, SAITO, KAZUKI, SHINOZAKI, MIKIHIKO, OGISO, HIDEO, NUREKI, OSAMU, NAKAO, NAOKI, YOKOYAMA, SHIGEYUKI, MATSUSUE, TOMOKAZU, MURAMATSU, HIROYUKI
• Format: Patent
• Language: English; French
• Published: 14.08.2003
• Edition: 7
• Subjects: AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUSPOLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR; CHEMISTRY; CRYSTAL GROWTH; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITHDEFINED STRUCTURE; REFINING BY ZONE-MELTING OF MATERIAL; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITHDEFINED STRUCTURE; SINGLE-CRYSTAL-GROWTH; TESTING; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL ORUNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL

Crystals of a complex of epithelial growth factor (EGF) with epithelial growth factor receptor (EGFR); crystals of a complex of EGFR with an EGFR activity controller; structural coordinates thereof; a method of screening an EGFR activity controller using these coordinates and a method of designing the same; a method of designing an EGFR mutant and an EGF mutant and a method of producing the same; an EGFR mutant and an EGF mutant obtained by the production method; a method of designing an epitope using the structural coordinate of the EGF/EGFR complex; a method of producing an anti-EGFR antibody and an anti-EGF antibody; antibodies obtained by this method; a polypeptide containing a domain forming an EGFR dimerizing site or its salt; and so on.