N-AMINOACETYL-PYRROLIDINE-2-CARBONITRILES AND THEIR USE AS DDP-IV INHIBITORS

• Main Authors: BORONKAY, EVA, BOVY, PHILIPPE, KAPUI, ZOLTAN, NAGY, LAJOS T, KANAI, KAROLY, BATA, IMRE, URBAN-SZABO, KATALIN, VARGA, MARTON, SZABO, TIBOR, BALAZS, LASZLO, ARANYI, PETER, SUSAN, EDIT, BATORI, SANDOR
• Format: Patent
• Language: English; French
• Published: 18.10.2011
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to new, potent DPP-IV enzyme inhibitors of the general formula (I), which contain fluorine atoms. Specifically, the invention relates to compounds of the general formula (I) (see formula I) - wherein R1 means a nitrogen-containing aromatic moiety consisting of one or two aromatic rings, which is, optionally mono- or disubstituted by one or two of the following groups: C1-4 alkyl groups, C1-4 alkoxy groups, halogen atom, trihalogenomethyl group, methylthio group, nitro group, cyano group, amino group or phenyl group; etc B stands for - a group of formula (1) or (2) or (3) or (4) or (5) or (6) or (7); (see formula 1), etc R2 stands for hydrogen atom or fluorine atom; R3 stands for fluorine atom; and salts, tautomers, solvates and hydrates thereof.