SUPERCRITICAL FLUIDS PROCESSING: PREPARATION OF PROTEIN MICROPARTICLES AND THEIR STABILISATION

A process for the co-precipitation of a substance with a stabiliser therefor , by a gas anti solvent process comprising introducing into a particle formati on vessel a supercritical fluid pure or mixed with a modifier; and a solution comprising said substance and said stabiliser dissolved in a solve...

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Bibliographic Details
Main Authors GENTILE, MARCO, DI PALMA, CESARE, CESTA, MARIA CANDIDA
Format Patent
LanguageEnglish
French
Published 01.05.2003
Edition7
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:A process for the co-precipitation of a substance with a stabiliser therefor , by a gas anti solvent process comprising introducing into a particle formati on vessel a supercritical fluid pure or mixed with a modifier; and a solution comprising said substance and said stabiliser dissolved in a solvent; so as said solvent is extracted from the solution by said supercritical fluid and co- precipitation of the substance and stabiliser occurs. The process may be carried out using an apparatus comprising a particle formation vessel (22) a nd a nozzle (27) having a central orifice (39) serving to introduce a solution of the substance and a plurality of outer orifices (41) serving to carry a flow of supercritical fluid into the particle formation vessel (22), such that th e solvent is extracted from the solution by the supercritical fluid and precipitation of micron sized particles of the substance/stabilizer occurs. The substance is preferably a protein of pharmaceutical interest, which is highly stabilized for storage by this process.
Bibliography:Application Number: CA20022464308