PROCESS FOR THE PREPARATION OF 3-SPIRO[CYCLOHEXAM-1,3'-[3H]INDOLIN-2'-ONE] DERIVATIVES

The invention relates to a process for the preparation of a compound of the formula (I) by reacting a compound of the formula (II) with a compound of th e formula (III) characterised by dissolving the compounds of the formula (II) and formula (III) in a water-inmiscible organic solvent in the presen...

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Main Authors MAJLATH, CSILLA, SZOMOR, TIBORNE, HEJA, GERGELYNE, HAJDU, FELIX, GONCZI, CSABA, SZVOBODA, GYORGYNE, NAGY, LAJOS, HERMECZ, ISTVAN, HEJA, GERGELY, SANTANE CSUTOR, ANDREA, CSIKOS, EVA
Format Patent
LanguageEnglish
French
Published 09.12.2008
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to a process for the preparation of a compound of the formula (I) by reacting a compound of the formula (II) with a compound of th e formula (III) characterised by dissolving the compounds of the formula (II) and formula (III) in a water-inmiscible organic solvent in the presence of a phase transfer catalyst, reacting with a.) an aqeuos solution of a base, or b.) a base in solid form directly and if desired transforming the compound o f formula (I) thus obtained into its salt.
Bibliography:Application Number: CA20022453946