SUBSTITUTED 4H-CHROMENES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF

The present invention is directed to substituted 4H-chromenes and analogs thereof, represented by Formula (UI) wherein R1-R5, A, Y and Z are defined herein. The present invention also relates to the discovery that compounds having Formula (I) are activators of caspases and inducers of apoptosis. The...

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Bibliographic Details
Main Authors ZHANG, HONG, STORER, RICHARD, CAI, SUI XIONG, JIANG, SONGCHUN
Format Patent
LanguageEnglish
French
Published 21.11.2002
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention is directed to substituted 4H-chromenes and analogs thereof, represented by Formula (UI) wherein R1-R5, A, Y and Z are defined herein. The present invention also relates to the discovery that compounds having Formula (I) are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditio ns in which controlled growth and spread of abnormal cells occurs.
Bibliography:Application Number: CA20022447010