DIAGNOSTIC IMAGING COMPOSITIONS, THEIR METHODS OF SYNTHESIS AND USE

Conjugate molecules comprising a ligand bonded to a polymer are disclosed. O ne such conjugate molecule comprises a ligand bonded to a polymer, a chelating agent bonded to the polymer, and a radioisotope chelated to the chelating agent. The conjugate molecules may be useful in detecting and/or treat...

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Bibliographic Details
Main Authors WEN, XIAOXIA, WALLACE, SYDNEY, WU, QING-PING, ELLIS, LEE M, LI, CHUN
Format Patent
LanguageEnglish
French
Published 07.11.2002
Edition7
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Conjugate molecules comprising a ligand bonded to a polymer are disclosed. O ne such conjugate molecule comprises a ligand bonded to a polymer, a chelating agent bonded to the polymer, and a radioisotope chelated to the chelating agent. The conjugate molecules may be useful in detecting and/or treating tumors or biological receptors. These conjugate molecules may be synthesized without the necessity of preactivation of the ligand using an SCN-polymer- chelating agent precursor. Conjugate molecules incorporating an annexin V ligand are particularly useful for visualizing apoptotic cells. Conjugate molecules incorporating a C225 ligand are particularly useful for targeting tumors expressing EGFR.
Bibliography:Application Number: CA20022444483