ARYL OXIME-PIPERAZINES USEFUL AS CCR5 ANTAGONISTS

In one embodiment, this invention provides a novel class of aryl oxime- piperazine compounds as antagonists of the CCR5 receptor, methods of preparing such compounds, pharmaceutical compositions containing one or more of the compounds, methods of preparing pharmaceutical formulations comprising one...

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Bibliographic Details
Main Authors PUSHPAVANAM, PRADEEP B, LIN, SUE Y, VICE, SUSAN, MCCOMBIE, STUART W, CLADER, JOHN W
Format Patent
LanguageEnglish
French
Published 10.10.2002
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:In one embodiment, this invention provides a novel class of aryl oxime- piperazine compounds as antagonists of the CCR5 receptor, methods of preparing such compounds, pharmaceutical compositions containing one or more of the compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention or amelioration of one or more of diseases associated with the CCR5 receptor. An illustrative inventive compound is shown below: (Formula I).
Bibliography:Application Number: CA20022442210