ANTIBIOTIC CALCIUM PHOSPHATE COATING

A process for applying a coating having a therapeutic agent such as an antibiotic to an implant uses the high surface area of a calcium phosphate coated metal implant as a repository for the therapeutic agent. The implant is coated with one or more layers of calcium phosphate minerals such as hydrox...

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Bibliographic Details
Main Authors ZITELLI, JOSEPH, SCOTT, CHRISTOPHER, HIGHAM, PAUL
Format Patent
LanguageEnglish
French
Published 18.03.2008
Subjects
APPLYING LIQUIDS OR OTHER FLUENT MATERIALS TO SURFACES, IN GENERAL
CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES
DISINFECTION, STERILISATION, OR DEODORISATION OF AIR
HUMAN NECESSITIES
HYGIENE
MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES
MEDICAL OR VETERINARY SCIENCE
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL
PERFORMING OPERATIONS
PROCESSES FOR APPLYING LIQUIDS OR OTHER FLUENT MATERIALS TOSURFACES, IN GENERAL
SPRAYING OR ATOMISING IN GENERAL
TRANSPORTING
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Summary:A process for applying a coating having a therapeutic agent such as an antibiotic to an implant uses the high surface area of a calcium phosphate coated metal implant as a repository for the therapeutic agent. The implant is coated with one or more layers of calcium phosphate minerals such as hydroxyapatite. After the crystalline layer is applied, which is usually done within an aqueous solution, the implant is dried and packaged. Immediately prior to implantation, the implant is removed from the package and the crystalline layer of calcium phosphate is wetted with an aqueous solution containing the therapeutic agent. L'invention se rapporte à un procédé d'application d'un revêtement contenant un agent thérapeutique tel qu'un antibiotique sur un implant effectué sur une zone à surface importante d'un implant métallique revêtu d'un phosphate de calcium servant de dépôt à l'agent thérapeutique. Cet implant est revêtu d'une ou plusieurs couches de minéraux de phosphate de calcium tels que hydroxyapatite. Après l'application de la couche cristalline, laquelle se fait habituellement au moyen d'une solution aqueuse, l'implant est séché et empaqueté. Juste avant l'implantation, l'implant est enlevé du paquet et la couche cristalline de phosphate de calcium est humidifiée avec la solution aqueuse contenant l'agent thérapeutique.
Bibliography:Application Number: CA20022432284