TARGETED THERAPEUTIC AGENTS

Therapeutic and imaging agents which are comprised of a targeting entity, a therapeutic or treatment entity and a linking carrier are provided. The linking carrier imparts additional advantages to the therapeutic agents, whi ch are not provided by conventional linking methods. Preferred agents of th...

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Main Authors BEDNARSKI, MARK DAVID, PEASE, JOHN S, SHEN, ZHI MIN, LI, KING CHUEN, DECHENE, NEAL EDWARD, TRULSON, JULIE, WARTCHOW, CHARLES AARON
Format Patent
LanguageEnglish
French
Published 18.04.2002
Edition7
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Therapeutic and imaging agents which are comprised of a targeting entity, a therapeutic or treatment entity and a linking carrier are provided. The linking carrier imparts additional advantages to the therapeutic agents, whi ch are not provided by conventional linking methods. Preferred agents of the present invention comprises a lipid construct, vesicle, liposome, or polymerized liposome. In some cases, the therapeutic or treatment entity is a radioisotope, chemotherapeutic agent, prodrug, toxin, or gene encoding a protein that exhibits cell toxicity. Preferably, the agent is further comprised of a stabilizing entity that imparts additional advantages to the therapeutic or imaging agent.
Bibliography:Application Number: CA20012425508