NOVEL INDOLE DERIVATIVES EXHIBITING CHYMASE-INHIBITORY ACTIVITIES AND PROCESS FOR PREPARATION THEREOF

• Main Authors: TAKEYASU, TAKUMI, SHIOKAWA, SOJIRO, KASAI, HIDENORI, HARIMAYA, KENZO, YANAGISAWA, YUMIKO, TAKENOUCHI, OSAMI, YAMAMOTO, YASUO
• Format: Patent
• Language: English; French
• Published: 11.12.2002
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Novel indole derivatives of the general formula (I) exhibiting useful chymas e- inhibitory activities are prepared by a novel chemical synthesis method. In said formula (I), wherein A is oxygen or nitrogen which may be substituted with alkyl; R1 and R2 are each independently hydrogen or alkyl, or may be united to form cycloalkyl, an aromatic ring, or a heterocycle; R3 is hydroge n, C1-10 alkyl, or the like; R4 is substituted alkyl; and R5 is hydrogen, halogeno, alkyl, or alkoxy.