NOVEL INDOLE DERIVATIVES EXHIBITING CHYMASE-INHIBITORY ACTIVITIES AND PROCESS FOR PREPARATION THEREOF

Novel indole derivatives of the general formula (I) exhibiting useful chymas e- inhibitory activities are prepared by a novel chemical synthesis method. In said formula (I), wherein A is oxygen or nitrogen which may be substituted with alkyl; R1 and R2 are each independently hydrogen or alkyl, or ma...

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Main Authors TAKEYASU, TAKUMI, SHIOKAWA, SOJIRO, KASAI, HIDENORI, HARIMAYA, KENZO, YANAGISAWA, YUMIKO, TAKENOUCHI, OSAMI, YAMAMOTO, YASUO
Format Patent
LanguageEnglish
French
Published 11.12.2002
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Novel indole derivatives of the general formula (I) exhibiting useful chymas e- inhibitory activities are prepared by a novel chemical synthesis method. In said formula (I), wherein A is oxygen or nitrogen which may be substituted with alkyl; R1 and R2 are each independently hydrogen or alkyl, or may be united to form cycloalkyl, an aromatic ring, or a heterocycle; R3 is hydroge n, C1-10 alkyl, or the like; R4 is substituted alkyl; and R5 is hydrogen, halogeno, alkyl, or alkoxy.
Bibliography:Application Number: CA20012411165