MACROCYCLIC NS3-SERINE PROTEASE INHIBITORS OF HEPATITIS C VIRUS COMPRISING ALKYL AND ARYL ALANINE P2 MOIETIES

The present invention discloses novel macrocyclic compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds . In another embodiment, the invention discloses pharmaceutical compositions comprising such macrocycles as well as methods of using them to treat d...

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Main Authors GANGULY, ASHIT K, CHAN, TIN-YAU, ARASAPPAN, ASHOK, GIRIJAVALLABHAN, VIYYOOR M, YAO, NANHUA H, VENKATRAMAN, SRIKANTH, MADISON, VINCENT S, PRONGAY, ANDREW J, CHEN, KEVIN X, MCKITTRICK, BRIAN A, NJOROGE, F. GEORGE
Format Patent
LanguageEnglish
French
Published 01.11.2001
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention discloses novel macrocyclic compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds . In another embodiment, the invention discloses pharmaceutical compositions comprising such macrocycles as well as methods of using them to treat disorders associated with the HCV protease.
Bibliography:Application Number: CA20012406532