A PYRIDINE-1-OXIDE DERIVATIVE, AND PROCESS FOR ITS TRANSFORMATION INTO PHARMACEUTICALLY EFFECTIVE COMPOUNDS

The invention relates to N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboxamidine and its optically active enantiomers. (R)-(-)-N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboxamidine and (S)-(+)-N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboxamidin...

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Bibliographic Details
Main Authors OTVOS, LASZLO, SCHNEIDERNE BARLAY, MARIA, GRUBER, LAJOS, TOMOSKOZI, ISTVAN, SZAKACSNE SCHMIDT, ANIKO, UROGDI, LASZLO, REIDER, FERENCNE, JEGESNE CSAKAI, ZITA, TOTH, JOZSEF
Format Patent
LanguageEnglish
French
Published 20.07.2010
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboxamidine and its optically active enantiomers. (R)-(-)-N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboxamidine and (S)-(+)-N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboxamidine. Furthermore, the invention relates to the preparation of N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboxyimidoyl chloride, which may be used as an active ingredient of medicaments, and the preparation of the optically active enantiomers of this compound using the compounds of the invention as intermediate substances.
Bibliography:Application Number: CA20012406266