SYNERGISTIC COMPOSITIONS CONTAINING CHOLINE BASE AND SUCCINIC ACID FOR INSULIN RESISTANCE AND DIABETES

• Main Authors: KOLESOVA, OLGA EVGENIEVNA, UKHANOVA, TATIYANA JURIEVNA, POMYTKIN, IGOR ANATOLIEVICH
• Format: Patent
• Language: English; French
• Published: 18.10.2001
• Edition: 7
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

This invention relates to compositions and methods for achieving a synergist ic effect in treating insulin resistance and diabetes mellitus in a mammal. Mor e specifically, this invention relates to synergistic composition comprising amounts of choline base or a pharmaceutically acceptable salt thereof and succinic acid or a pharmaceutically acceptable salt thereof, which are presented in amounts sufficient to cause synergistic effects in treating insulin resistance and diabetes mellitus in a mammal. Further, this inventio n relates to methods for achieving a synergistic effects in treating insulin resistance and diabetes mellitus in a mammal, which methods comprise administering to said mammal, either stepwise or simultaneously, effective amounts of choline base or a pharmaceutically acceptable salt thereof and succinic acid or a pharmaceutically acceptable salt thereof. Further, this invention relates to a novel derivative of choline. More specifically, this invention relates to bis(2-hydroxy-N,N,N-trimethylethanaminium) succinate, t he novel salt of choline formed by choline base and succinic acid in the molar ratio 2:1, a process for producing the salt, and use of the salt in medicine , preferably for the manufacture of a medicament for treating insulin resistance, hyperlipidemia, dyslipidemia, or diabetes mellitus.