A PROCESS FOR THE PREPARATION OF EPOTHILONE ANALOGS AND INTERMEDIATES
The present invention relates to a process for the preparation of epothilone analogs by initially forming novel ring-opened epothilones and carrying out a macrolactamization reaction thereon. The subject process is amenable to being carried out in a single reaction vessel without isolation of the in...
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Main Authors | , , , |
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Format | Patent |
Language | English French |
Published |
01.05.2012
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention relates to a process for the preparation of epothilone analogs by initially forming novel ring-opened epothilones and carrying out a macrolactamization reaction thereon. The subject process is amenable to being carried out in a single reaction vessel without isolation of the intermediate compound and provides at least about a three-fold increase in yield over prior processes for preparing the desired epothilone analogs. |
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Bibliography: | Application Number: CA20012404212 |