PYRAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAININGTHEM, AND INTERMEDIATES THEREFOR

Pyrazine derivatives represented by general formula [1]: (see formula 1) wherein the variables are as defined in the specification, or salts thereof have an excellent antiviral activity and are useful as a therapeutic agent for treating viral infections. Further, fluoropyrazine-carboxamide derivativ...

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Bibliographic Details
Main Authors FURUTA, YOUSUKE, EGAWA, HIROYUKI, HAMAMOTO, SHOICHI, UEHARA, SAYURI, YONEZAWA, KENJI, SUGITA, JUN
Format Patent
LanguageEnglish
French
Published 23.06.2009
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Summary:Pyrazine derivatives represented by general formula [1]: (see formula 1) wherein the variables are as defined in the specification, or salts thereof have an excellent antiviral activity and are useful as a therapeutic agent for treating viral infections. Further, fluoropyrazine-carboxamide derivatives represented by general formula [2]: (see formula 2) wherein the variables are as defined in the specification, or salts thereof are useful as an intermediate for production of the compounds of general formula [1], and as an intermediate for production of the fluoropyrazine-carboxamide derivatives of which one typical example is 6-fluoro-3-hyroxy-2-pyrazine- carboxamide having an antiviral activity.
Bibliography:Application Number: CA20012398620