NOVEL 1,8-NAPHTHYRIDIN-2(1H)-ONE DERIVATIVES

Development of selective PDE IV inhibitors excellent in antiasthmatic activity, safety, and so on. Compounds of general formula (1) or pharmaceutically acceptable salts thereof exhibit a selective PDE IV inhibiting effect and are useful as drugs, particularly antiasthmatic agent; wherein A is an opt...

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Main Authors NOSE, TAKASHI, AOTSUKA, TOMOJI, ISHITANI, KOUKI, KUMAZAWA, KENTAROU, WAGATSUMA, NAGATOSHI
Format Patent
LanguageEnglish
French
Published 15.06.2010
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Development of selective PDE IV inhibitors excellent in antiasthmatic activity, safety, and so on. Compounds of general formula (1) or pharmaceutically acceptable salts thereof exhibit a selective PDE IV inhibiting effect and are useful as drugs, particularly antiasthmatic agent; wherein A is an optionally substituted 5- or 6-membered heteroaryl group or a fused ring thereof with benzene; B is carbon or nitrogen; R1 is hydrogen, lower alkyl, trifluoromethyl, hydroxyl, lower alkoxy, a residue of a carboxylic acid or a derivative thereof, amino, or a group bearing an amino nitrogen atom; R2 is hydrogen, halogeno, cyano, nitro, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, trifluoromethyl, hydroxyl, lower alkoxy, a residue of a carboxylic acid or a derivative thereof, amino, or a group bearing an amino nitrogen atom; and m is an integer of 1 to 8.
Bibliography:Application Number: CA20002393650