DOSAGE FORMS AND METHODS FOR PROVIDING EFFECTIVE REBOXETINE THERAPY WITH ONCE-A-DAY DOSING

Dosage forms and methods for providing sustained release of reboxetine are provided. The sustained release dosage forms provide therapeutically effective average steady-state plasma reboxeti ne concentrations when administered once per day. This once-a-day dosing regimen results in only one peak pla...

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Main Authors SEROFF, SYLVIA, AYER, ATUL D, NIXON, PHILLIP R, DESJARDIN, MICHAEL A, BHATT, PADMANABH, LAM, ANDREW C, YAM, NOYMI, EDGREN, DAVID E
Format Patent
LanguageEnglish
French
Published 29.12.2009
Subjects
BABY COMFORTERS
CHEMISTRY
CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICALPURPOSES
DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY
DEVICES FOR RECEIVING SPITTLE
DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGINGPHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL ORADMINISTERING FORMS
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Dosage forms and methods for providing sustained release of reboxetine are provided. The sustained release dosage forms provide therapeutically effective average steady-state plasma reboxeti ne concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plasma reboxetine concentration occurrence in each 24 hour period. In addition, the peak plasma reboxetine concentration occurs at a later time following do se administration and exhibits a lesser magnitude than the peak plasma reboxetine concentration that occurs following administratio n of reboxetine in an immediate-release dosage form.
Bibliography:Application Number: CA20002384624