INDAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING PROTEIN KINASES, AND METHODS FOR THEIR USE

Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The inv...

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Main Authors LUU, HIEP THE, HUA, YE, KANIA, ROBERT STEVEN, BENDER, STEVEN LEE, REICH, SIEGFRIED HEINZ, CRIPPS, STEPHAN JAMES, BRAGANZA, JOHN F, JOHNSON, THEODORE OTTO JR, VARNEY, MICHAEL DAVID, PALMER, CYNTHIA LOUISE, THOMAS, CHRISTINE, WALLACE, MICHAEL BRENNAN, COLLINS, MICHAEL RAYMOND, TENG, MIN, JOHNSON, MICHAEL DAVID, TEMPCZYK-RUSSELL, ANNA MARIA, BORCHARDT, ALLEN J
Format Patent
LanguageEnglish
French
Published 18.11.2008
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer an d other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
Bibliography:Application Number: CA20002383630