OPTICALLY ACTIVE QUINOLINE CARBOXYLIC ACID DERIVATIVES WITH 7-PYRROLIDINE SUBSTITUENTS CAUSING OPTICAL ACTIVITY AND A PROCESS FOR THE PREPARATION THEREOF

The present invention relates to optically active quinoline carboxylic acid derivatives, pharmaceutically acceptable salts thereof, solvates thereof, an d a process for preparation thereof. More particularly, the present invention relates to optically active quinoline carboxylic acid derivatives hav...

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Main Authors CHOI, DONG RACK, KIM, NAM DOO, JIN, YOON HO, SHIN, JUNG HAN, YOON, SUNG JUNE, YANG, WANG YONG, LEE, JIN SOO, LEE, CHI WOO, CHUNG, YONG HO, KIM, IK HOE, SONG, WAN JIN
Format Patent
LanguageEnglish
French
Published 30.11.2000
Edition7
Subjects
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to optically active quinoline carboxylic acid derivatives, pharmaceutically acceptable salts thereof, solvates thereof, an d a process for preparation thereof. More particularly, the present invention relates to optically active quinoline carboxylic acid derivatives having 4- aminomethyl-4-methyl-3-(Z)-alkoxyiminopyrrolidine substitutes causing optica l activity at 7-position of quinolone. As the compounds of the present inventi on have superior antibacterial activity to enantiomers thereof, racemic mixture s thereof and other antibacterial agents, have a good pharmacokinetic characteristic and show no phototoxicity, the compound of this invention is useful for an antibacterial agent.
Bibliography:Application Number: CA20002374767