A PROCESS FOR PURIFICATION OF PROANTHOCYANIDIN OLIGOMER

Methods for purifying proanthocyanidin oligomers which contain di- to pentamers including: A) a method comprising effecting solid/liquid extractio n of a material containing the above oligomers or a crude purification product thereof by using methyl acetate as the liquid phase; B) a method comprisin...

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Main Authors KANDA, TOMOMASA, MATSUOKA, TAKAKO, YANAGIDA, AKIO, KAMIMURA, AYAKO, HIEDA, KAZUO, HONDA, SHINKICHI, TAKAHASHI, TOMOYA
Format Patent
LanguageEnglish
French
Published 02.11.2000
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Methods for purifying proanthocyanidin oligomers which contain di- to pentamers including: A) a method comprising effecting solid/liquid extractio n of a material containing the above oligomers or a crude purification product thereof by using methyl acetate as the liquid phase; B) a method comprising preliminarily treating a material containing the above oligomers, a crude purification product thereof or a solution of the same with a hydrolase; and C) a method comprising subjecting a material containing the above oligomers or a crude purification product thereof to normal phase silica gel liquid chromatography by using as a mobile phase a solvent selected from the group consisting of ester solvents, ketone solvents, hydrocarbon solvents, ether solvents and alcohol solvents or a mixture of two or more of the same to thereby separate and purify the oligomers into individual homogeneous oligomers depending on the degree of polymerization.
Bibliography:Application Number: CA20002370238