N-[2-HYDROXY-3-(1-PIPERIDINYL)PROPOXY]PYRIDINE-1-OXIDE-3-CARBOXIMIDOYL CHLORIDE AND ITS USE IN THE TREATMENT OF INSULIN RESISTANCE

The invention relates to N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboximidoyl chloride, its stereoisomers and the acid addition salts thereof, pharmaceutical compositions containing the same, the use of these compounds in the treatment of pathological insulin resistance, and for...

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Main Authors KOMAROMI, ANDRAS, KARDOS, MIHALYNE, NAGY, KAROLY, MARVANYOS, EDE, KURTHY, MARIA, UROGDI, LASZLO, NAGY, MELINDA, SZILBEREKY, JENO, CSAKAI, ZITA, MOGYOROSI, TAMAS, TOROK, MAGDOLNA, BIRO, KATALIN, KORANYI, LASZLO, BARABAS, MIHALY, NAGY, ZOLTAN
Format Patent
LanguageEnglish
French
Published 04.01.2011
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboximidoyl chloride, its stereoisomers and the acid addition salts thereof, pharmaceutical compositions containing the same, the use of these compounds in the treatment of pathological insulin resistance, and for the treatment of pathological conditions associated therewith, for the treatment of pathological insulin resistance, and the treatment of pathological conditions associated therewith, by simultaneous treatment and prevention of diabetes-induced chronic complications, especially retinopathy, neuropathy and nephropathy and/or with simultaneous increasing pathologically decreased peripheral neuroregeneration caused by diabetes and methods of treatment.
Bibliography:Application Number: CA20002360451