METHOD FOR PRODUCING L-PHENYLEPHRINE HYDROCHLORIDE
The present invention relates to an improved process for preparing L- phenylephrine hydrochloride 3 on an industrial scale by asymmetric hydrogenation as the ke y step and a special sequence of subsequent steps, using [Rh(COD)Cl]2 as catalyst and a chiral, two-pronged phosphine ligand such as (2R, 4...
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Main Authors | , , |
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Format | Patent |
Language | English French |
Published |
24.03.2009
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention relates to an improved process for preparing L- phenylephrine hydrochloride 3 on an industrial scale by asymmetric hydrogenation as the ke y step and a special sequence of subsequent steps, using [Rh(COD)Cl]2 as catalyst and a chiral, two-pronged phosphine ligand such as (2R, 4R)-4-(dicyclohexylphosphino)-2- (diphenylphosphino-methyl)-N-methyl-aminocarbonyl-pyrrolidine as the catalys t system. |
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Bibliography: | Application Number: CA20002355938 |