METHOD FOR PRODUCING L-PHENYLEPHRINE HYDROCHLORIDE

The present invention relates to an improved process for preparing L- phenylephrine hydrochloride 3 on an industrial scale by asymmetric hydrogenation as the ke y step and a special sequence of subsequent steps, using [Rh(COD)Cl]2 as catalyst and a chiral, two-pronged phosphine ligand such as (2R, 4...

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Bibliographic Details
Main Authors WOLTER, LIENHARD, KLINGLER, FRANZ DIETRICH, DIETRICH, WOLFGANG
Format Patent
LanguageEnglish
French
Published 24.03.2009
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention relates to an improved process for preparing L- phenylephrine hydrochloride 3 on an industrial scale by asymmetric hydrogenation as the ke y step and a special sequence of subsequent steps, using [Rh(COD)Cl]2 as catalyst and a chiral, two-pronged phosphine ligand such as (2R, 4R)-4-(dicyclohexylphosphino)-2- (diphenylphosphino-methyl)-N-methyl-aminocarbonyl-pyrrolidine as the catalys t system.
Bibliography:Application Number: CA20002355938