INDOLE DERIVATIVES AS ANTI-INFLAMMATION AGENTS

The use of a 3-substituted indole compound of formula (I) or a pharmaceutically acceptable salt, amide or ester thereof; X is CH2 or SO2 an d R1, R2, R3, R4, R5, R6 and R7 are certain specified organic moieties, for us e in the preparation of a medicament for the inhibition of monocyte chemoattracta...

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Bibliographic Details
Main Authors KETTLE, JASON, FAULL, ALAN WELLINGTON
Format Patent
LanguageEnglish
French
Published 10.08.2000
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The use of a 3-substituted indole compound of formula (I) or a pharmaceutically acceptable salt, amide or ester thereof; X is CH2 or SO2 an d R1, R2, R3, R4, R5, R6 and R7 are certain specified organic moieties, for us e in the preparation of a medicament for the inhibition of monocyte chemoattractant protein-1 and/or RANTES induced chemotaxis. Pharmaceutical compositions containing certain compounds of formula (I) and novel compounds of formula (I) are also described and claimed.
Bibliography:Application Number: CA20002355734