METHOD AND DEVICES FOR APPLYING SUBSTANCES TO A SUPPORT, ESPECIALLY MONOMERS FOR THE COMBINATORIAL SYNTHESIS OF MOLECULE LIBRARIES

• Main Authors: POUSTKA, ANNEMARIE, DUBEL, STEFAN, BREITLING, FRANK, SAFFRICH, RAINER, GROSS, KARL-HEINZ
• Format: Patent
• Language: English; French
• Published: 08.03.2011
• Subjects: APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS THEREFOR; BEER; BIOCHEMISTRY; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; COMBINATORIAL CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; DERIVATIVES THEREOF; ENZYMOLOGY; GENERAL METHODS OF ORGANIC CHEMISTRY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES; MEASURING; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PEPTIDES; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PHYSICS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; SUGARS; TESTING; THEIR RELEVANT APPARATUS; TRANSPORTING; VINEGAR; WINE

According to the inventive method monomers for the combinatorial synthesis of molecule libraries are embedded in a solid matrix at a temperature below 90°C. The monomers that are embedded in the matrix form solid transport units, which are subsequently applied to the support in a spatially defined manner, where they adopt a solid or gel-like stage of aggregation. The method can be carried out with a laser printer or a laser copier or an ink jet printer. The monomers within the matrix are then mobilized by melting by heat or chemical vapour. Thereby, the monomers couple to reactive groups on the solid support. If multiple layers are repeatedly applied to the support in precise positions, the combinatorial synthesis of an array of oligomers ensues.