PROCESS FOR THE PRODUCTION OF ENANTIOMERICALLY PURE OR OPTICALLY ENRICHED SERTRALINE-TETRALONE USING CONTINUOUS CHROMATOGRAPHY

A process for the production of enantiomerically pure or optically enriched sertraline-tetralone from a mixture containing two enantiomers using continuous chromatography. The chromatography comprises a liquid mobile phas e comprising at least one polar solvent and a solid chiral stationary phase co...

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Bibliographic Details
Main Authors GEISER, FIONA, GUINN, ROBERT M, QUALLICH, GEORGE J, DAPREMONT, OLIVER, GUHAN, SUBRAMANIAN S, ZHANG, TONG
Format Patent
LanguageEnglish
French
Published 11.11.1999
Edition6
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:A process for the production of enantiomerically pure or optically enriched sertraline-tetralone from a mixture containing two enantiomers using continuous chromatography. The chromatography comprises a liquid mobile phas e comprising at least one polar solvent and a solid chiral stationary phase comprising a derivatized polysaccharide that is selected from the amylosic, cellulosic, chitosan, xylan, curdlan, dextran, and inulan class of polysaccharides.
Bibliography:Application Number: CA19992342201