PROCEDURE FOR THE CHROMATOGRAPHIC PURIFICATION OF INSULINS

The invention relates to an improved method for chromatographically purifyin g insulins. The invention is characterized in that a pressure-stable, organic, and polymeric chromatographic material is used as a stationary phase, and in that the mobile phase contains at least one organic solvent which c...

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Bibliographic Details
Main Authors BICKER, RICHARD, RICHARD, FRANK, SIEVERS, WERNER, KELLER, REINHOLD, VON EYSMONDT, JORG, DESCH, DIETER
Format Patent
LanguageEnglish
French
Published 07.04.2009
Subjects
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SEPARATION
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
TESTING
THEIR RELEVANT APPARATUS
TRANSPORTING
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Summary:The invention relates to an improved method for chromatographically purifyin g insulins. The invention is characterized in that a pressure-stable, organic, and polymeric chromatographic material is used as a stationary phase, and in that the mobile phase contains at least one organic solvent which can be mixed with water, and contains at least one buffering agent. In addition, the invention is characterized in that the pH value ranges from 7 to 11.
Bibliography:Application Number: CA19992341355