PROCESS FOR ALKYLATING HINDERED SULFONAMIDES USEFUL IN THE PRODUCTION OF MATRIX METALLOPROTEINASE INHIBITORS

• Main Authors: HAWKINS, JOEL MICHAEL, ANDRESEN, BRIAN MICHAEL, HAMMEN, PHILIP DIETRICH
• Format: Patent
• Language: English; French
• Published: 21.10.1999
• Edition: 6
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; APPARATUS THEREFOR; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR RELEVANT APPARATUS; TRANSPORTING

The present invention relates to a process for the preparation of compounds of formula (b), in which a compound of formula (V) is reacted with a compound of formula (VI). The resulting compound of formula (IV) is reduced to a compound of formula (III) which is hydrolysed to a compound of formula (b). Alternatively, a compound of formula (IV) is hydrolysed to a compound of formula (a) which is reduced to a compound of formula (b). Compounds of formula (IV) are novel. In the formulae the variables are as defined in the claims. Compounds of formula (b) are useful as intermediates in the preparation of matrix metalloproteinase inhibitors.