INDUCTION OF IMMUNITY AGAINST TUMOR SELF-ANTIGENS

This invention provides methods and compositions for breaking tolerance to a self-antigen, especially in the context of a tumor-associated antigen. In one embodiment, the method utilized altered tumor antigens or tumor antigens derived from heterologous species to break immunological tolerance and i...

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Bibliographic Details
Main Authors GREGORY, RICHARD J, KAPLAN, JOHANNE
Format Patent
LanguageEnglish
French
Published 23.09.1999
Edition6
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:This invention provides methods and compositions for breaking tolerance to a self-antigen, especially in the context of a tumor-associated antigen. In one embodiment, the method utilized altered tumor antigens or tumor antigens derived from heterologous species to break immunological tolerance and induce a cross-reactive immune response against the corresponding native or selfantigen.
Bibliography:Application Number: CA19992322624