COMPOSITIONS AND METHODS FOR INDUCING GENE EXPRESSION
The present invention provides recombinant nucleic acid molecules encoding a chimeric transactivator protein including a DNA binding domain of a DNA binding protein and a protein domain capable of transcriptional activation. The present invention also provides recombinant viral and non-viral vectors...
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Main Authors | , |
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Format | Patent |
Language | English French |
Published |
10.06.1999
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Edition | 6 |
Subjects | |
Online Access | Get full text |
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Summary: | The present invention provides recombinant nucleic acid molecules encoding a chimeric transactivator protein including a DNA binding domain of a DNA binding protein and a protein domain capable of transcriptional activation. The present invention also provides recombinant viral and non-viral vectors that are able to infect and/or transfect and sustain expression of a biologically active chimeric transactivor proteins in mammalian cells. Also provided are host cell lines and non-human transgenic animals capable of expressing biologically active chimeric transactivator proteins. In another aspect, compositions and methods for treating or preventing ischemic damage associated with hypoxia-related disorders are provided. |
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Bibliography: | Application Number: CA19982311643 |