CYCLIC AMINE DERIVATIVES AND THEIR USE AS DRUGS

A compound represented by general formula (I), a pharmaceutically acceptable acid addition salt thereof or a pharmaceutically acceptable C1-C6 alkyl addition salt thereof, and their medical applications. Since these compounds inhibit the action of chemokines such as MIP-1.alpha. and/or MCP-1 on targ...

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Main Authors TARBY, CHRISTINE M, MUROGA, YUMIKO, IMAI, MINORU, SHIOTA, TATSUKI, TAKENOUCHI, OSAMI, FURUYA, MINORU, TEIG, STEVEN L, SUDOH, MASAKI, ENDO, NORIAKI, HADA, TAKAHIKO, MORITA, TAKUYA, TSUTSUMI, TAKAHARU, KATAOKA, KEN-ICHIRO, MOREE, WILNA, SOGAWA, RYO
Format Patent
LanguageEnglish
French
Published 14.10.2008
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A compound represented by general formula (I), a pharmaceutically acceptable acid addition salt thereof or a pharmaceutically acceptable C1-C6 alkyl addition salt thereof, and their medical applications. Since these compounds inhibit the action of chemokines such as MIP-1.alpha. and/or MCP-1 on target cells, they may be useful as a therapeutic drug and/or preventative drug in diseases, such as atherosclerosis, rheumatoid arthritis, and the like where blood monocytes and lymphocytes infiltrate into tissues.
Bibliography:Application Number: CA19982309328